Poplarville Campus:
- Baptist Student Union
- DECA
- Fellowship of Christian Athletes
- Honors Institute
- Phi Theta Kappa
- PRCC Gaming and Strategy Club
- Skills USA
- STEM Club (Science, Technology, Engineering, and Mathematics)
- Student Government Association
- Student Nurses Association
- Young Americans for Liberty
Forrest County Campus:
- American Dental Hygienists’ Association
- Baptist Student Union
- DECA
- Fellowship of Christian Athletes
- Forrest County Center Science Club
- History and Humanities Club
- Mu Alpha Theta
- National Technical Honor Society
- Phi Theta Kappa-Beta Tau Gamma Chapter
- Science Club
- Sigma Kappa Delta National English Honor Society
- Skills USA
- Student Government Association
- Videogame Club
Hancock Campus:
- Baptist Student Union
- Phi Theta Kappa